The Simpsons (1989)

S19E9 Eternal Moonshine of the Simpson Mind

After downing Moe's strongest concoction, the Forget-Me-Shot, Homer finds himself with no recollection of his life and family. This episode cleverly parodies "Eternal Sunshine of the Spotless Mind" and "It's a Wonderful Life," as he navigates a world where he’s forgotten everyone he loves. As Homer grapples with his lost memories, he begins to understand the true value of family and the importance of his past.