Supernatural (2005)

S1E13 Route 666

Dean receives a call from his first love, Cassie, an African-American woman, who seeks his help in Mississippi to look into a series of racially charged murders. Each death is connected to a strange truck that appears to have no driver and leaves no trace. As Dean delves into the investigation, Sam is taken aback by this unfamiliar side of his brother, who grapples with lingering emotions for Cassie amidst the troubling circumstances.